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Target
Type II restriction enzyme ScaI
Ligand
BDBM50164888
Substrate
n/a
Meas. Tech.
ChEMBL_504717 (CHEMBL990277)
IC50
>400000±n/a nM
Citation
 Suzuki, K; Yahara, S; Maehata, K; Uyeda, M Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod 64:204-7 (2001) [PubMed]  Article 
Target
Name:
Type II restriction enzyme ScaI
Synonyms:
T2S1_STRCS | Type-2 restriction enzyme ScaI | scaIR
Type:
PROTEIN
Mol. Mass.:
25466.25
Organism:
Streptomyces caespitosus
Description:
ChEMBL_504717
Residue:
227
Sequence:
MINDQLPRWVREARVGTRTGGPAMRPKTSDSPYFGWDSEDWPEVTRQLLSEQPLSGDTLVDAVLASWESIFESRLGSGFHIGTQIRPTPQVMGFLLHALIPLELANGDPSWRADLNSSEKDLVYQPDHKYSIEMKTSSHKDQIFGNRSFGVENPGKGKKAKDGYYVAVNFEKWSDAPGRLPRIRTIRYGWLDHTDWVAQKSQTGQQSSLPAVVSNTQLLAIHTGGQR
  
Inhibitor
Name:
BDBM50164888
Synonyms:
6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-3H-benzofuran-2-one | CHEMBL195416 | isoaurostatin
Type:
Small organic molecule
Emp. Form.:
C15H10O4
Mol. Mass.:
254.2375
SMILES:
Oc1ccc(\C=C2\C(=O)Oc3cc(O)ccc23)cc1
Structure:
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