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Target
Sodium/hydrogen exchanger
Ligand
BDBM16173
Substrate
n/a
Meas. Tech.
ChEMBL_506147 (CHEMBL938726)
IC50
98000±n/a nM
Citation
 Pedersen, SF; King, SA; Nygaard, EB; Rigor, RR; Cala, PM NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem 282:19716-27 (2007) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
90748.00
Organism:
Amphiuma tridactylum
Description:
ChEMBL_506147
Residue:
813
Sequence:
MFQMWKRMACDCLGYPFRGIISPLGSICFFGAFLLFILPIGVAAFKSEAMLATEPSRSRILDDSPGITPAPTLTAHPTTNTSGNNSAGGHGKGHKVFPVLGFDYLRVRIPFEISLWILLASLMKLGFHVIPTVSNVVPESCLLIVVGLLVGGLIKGVGETPPVLHSDTFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVLGTLWNTFCIGSLLFAVCQISGTSLNGVGLLANLLFGAIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFGTFDQVTFKDIFLGFLSFFVVALGGVFVGVVYGIVAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGPHEWNWTFVMSTLLLCLIARVLGVLGLTSVINRFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDHHHFPKRNMFLTAIITVIFFTVFVQGMTIRPLVELLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSTEPQLIAFYHKMELKQAIELVESGGLGRIPSAVSTVSMQNIQPKAKPTDRFIPALSKVKEEEIRKILRTNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKAHQLEQRMNNYLTVPAHKMDSPTMTRARVGSDPMAYEPKANIRDLPTITIDPASPESVDIVNEEKKSLPTEEEEEEEEGIVMTAKEPPSPGTDDVFTPGAGDSPNNQRLMRCLSDPGPQPEPEEQDPFIKKEK
  
Inhibitor
Name:
BDBM16173
Synonyms:
3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride | 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide | Amiloride | Amipramidin | CHEMBL945
Type:
Small organic molecule
Emp. Form.:
C6H8ClN7O
Mol. Mass.:
229.627
SMILES:
NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Structure:
Search PDB for entries with ligand similarity: