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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50265433
Substrate
n/a
Meas. Tech.
ChEMBL_497294 (CHEMBL995856)
Ki
0.350000±n/a nM
Citation
 Mercer, SL; Shaikh, J; Traynor, JR; Matsumoto, RR; Coop, A Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands. Eur J Med Chem 43:1304-8 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50265433
Synonyms:
1-Isobutyl-4-phenylpiperidine-4-carbonitrile | CHEMBL486190
Type:
Small organic molecule
Emp. Form.:
C16H22N2
Mol. Mass.:
242.3593
SMILES:
CC(C)CN1CCC(CC1)(C#N)c1ccccc1
Structure:
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