Reaction Details Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM50224185
Substrate
n/a
Meas. Tech.
ChEMBL_555531 (CHEMBL963791)
Ki
180±n/a nM
Citation
Chen, C; Tucci, FC; Jiang, W; Tran, JA; Fleck, BA; Hoare, SR; Wen, J; Chen, T; Johns, M; Markison, S; Foster, AC; Marinkovic, D; Chen, CW; Arellano, M; Harman, J; Saunders, J; Bozigian, H; Marks, D Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. Bioorg Med Chem 16:5606-18 (2008) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 5
Synonyms:
MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36612.92
Organism:
Homo sapiens (Human)
Description:
P33032
Residue:
325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
Inhibitor
Name:
BDBM50224185
Synonyms:
1-{2-[(1S)-(methylaminoacetamido)-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(2-fluoro-4-chlorophenyl)propionyl]piperazine | CHEMBL240571 | N-((S)-1-(2-(4-((R)-3-(4-chloro-2-fluorophenyl)-2-methylpropanoyl)piperazin-1-yl)-5-methylphenyl)-2-methylpropyl)-2-(methylamino)acetamide
Type:
Small organic molecule
Emp. Form.:
C28H38ClFN4O2
Mol. Mass.:
517.078
SMILES:
CNCC(=O)N[C@@H](C(C)C)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1F |r|