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Target
Melanocortin receptor 4
Ligand
BDBM50261223
Substrate
n/a
Meas. Tech.
ChEMBL_533293 (CHEMBL973312)
Ki
26±n/a nM
Citation
 Chen, C; Tucci, FC; Jiang, W; Tran, JA; Fleck, BA; Hoare, SR; Wen, J; Chen, T; Johns, M; Markison, S; Foster, AC; Marinkovic, D; Chen, CW; Arellano, M; Harman, J; Saunders, J; Bozigian, H; Marks, D Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. Bioorg Med Chem 16:5606-18 (2008) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50261223
Synonyms:
1-{2-[(1S)-Amino-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(2-methoxy-4-chlorophenyl)-propionyl]piperazine | CHEMBL466346
Type:
Small organic molecule
Emp. Form.:
C25H33ClFN3O2
Mol. Mass.:
462
SMILES:
COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(CC1)c1c(F)cccc1[C@@H](N)C(C)C |r|
Structure:
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