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Target
Gastric inhibitory polypeptide
Ligand
BDBM50244233
Substrate
n/a
Meas. Tech.
ChEMBL_491828 (CHEMBL945218)
IC50
2500±n/a nM
Citation
 Kim, RM; Chang, J; Lins, AR; Brady, E; Candelore, MR; Dallas-Yang, Q; Ding, V; Dragovic, J; Iliff, S; Jiang, G; Mock, S; Qureshi, S; Saperstein, R; Szalkowski, D; Tamvakopoulos, C; Tota, L; Wright, M; Yang, X; Tata, JR; Chapman, K; Zhang, BB; Parmee, ER Discovery of potent, orally active benzimidazole glucagon receptor antagonists. Bioorg Med Chem Lett 18:3701-5 (2008) [PubMed]  Article 
Target
Name:
Gastric inhibitory polypeptide
Synonyms:
GIP | GIP_HUMAN
Type:
PROTEIN
Mol. Mass.:
17110.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_491828
Residue:
153
Sequence:
MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQREARALELASQANRKEEEAVEPQSSPAKNPSDEDLLRDLLIQELLACLLDQTNLCRLRSR
  
Inhibitor
Name:
BDBM50244233
Synonyms:
CHEMBL513067 | trans-4-(((4-tert-butylcyclohexyl)(5-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)-N-(1H-tetrazol-5-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C28H36N8O2
Mol. Mass.:
516.6378
SMILES:
COc1ccc2n(C)c(nc2c1)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)[C@H]1CC[C@@H](CC1)C(C)(C)C |r,wU:28.31,wD:31.38,(13.19,-24.98,;12.38,-26.29,;13.12,-27.64,;12.32,-28.96,;13.06,-30.31,;14.59,-30.34,;15.59,-31.52,;14.82,-32.85,;17.02,-30.92,;16.89,-29.39,;15.39,-29.03,;14.66,-27.68,;18.35,-31.7,;18.34,-33.24,;19.67,-34.02,;21,-33.25,;22.33,-34.03,;22.32,-35.57,;20.97,-36.33,;19.65,-35.55,;23.65,-36.35,;23.64,-37.89,;24.99,-35.59,;26.32,-36.37,;26.83,-37.81,;28.37,-37.78,;28.81,-36.3,;27.55,-35.43,;19.68,-30.94,;19.68,-29.4,;21.03,-28.64,;22.36,-29.42,;22.34,-30.96,;21.01,-31.72,;23.7,-28.67,;25.02,-27.89,;24.47,-30,;22.93,-27.33,)|
Structure:
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