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Target
Protein kinase C zeta type
Ligand
BDBM50252376
Substrate
n/a
Meas. Tech.
ChEMBL_491742 (CHEMBL950545)
IC50
1210±n/a nM
Citation
 Whitson, EL; Bugni, TS; Chockalingam, PS; Concepcion, GP; Harper, MK; He, M; Hooper, JN; Mangalindan, GC; Ritacco, F; Ireland, CM Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp. J Nat Prod 71:1213-7 (2008) [PubMed]  Article 
Target
Name:
Protein kinase C zeta type
Synonyms:
KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta
Type:
Enzyme
Mol. Mass.:
67649.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
592
Sequence:
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
  
Inhibitor
Name:
BDBM50252376
Synonyms:
CHEMBL455091 | Topsentiasterol sulfate E
Type:
Small organic molecule
Emp. Form.:
C31H49O13S3
Mol. Mass.:
725.91
SMILES:
CC(C)C1(CC[C@@H](C)[C@H]2CC[C@@]3(C)[C@@H]4C[C@H](OS([O-])(=O)=O)[C@H]5[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](C[C@]5(C)C4=CC[C@]23C)OS([O-])(=O)=O)CC1C |r,c:36|
Structure:
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