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Target
Cathepsin B
Ligand
BDBM50252489
Substrate
n/a
Meas. Tech.
ChEMBL_487505 (CHEMBL1016567)
IC50
23±n/a nM
Citation
 Kim, SH; Jhon, DJ; Song, JH; No, JS; Kang, NS Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts. Bioorg Med Chem Lett 18:3988-91 (2008) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50252489
Synonyms:
2-(3-methyl-2-(3-(trifluoromethyl)phenylamino)butanoyl)piperazine-1-carbonitrile | CHEMBL521987
Type:
Small organic molecule
Emp. Form.:
C17H21F3N4O
Mol. Mass.:
354.37
SMILES:
CC(C)C(Nc1cccc(c1)C(F)(F)F)C(=O)N1CCCCN1C#N
Structure:
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