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TargetCathepsin S
LigandBDBM50252652
Substrate/Competitorn/a
Meas. Tech.ChEMBL_487680
IC50 24±n/a nM
Citation Irie, OEhara, TIwasaki, AYokokawa, FSakaki, JHirao, HKanazawa, TTeno, NHoriuchi, MUmemura, IGunji, HMasuya, KHitomi, YIwasaki, GNonomura, KTanabe, KFukaya, HKosaka, TSnell, CRHallett, A Discovery of selective and nonpeptidic cathepsin S inhibitors. Bioorg Med Chem Lett18:3959-62 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50252652
NameBDBM50252652
Synonyms:7-(2-cyclohexylethyl)-6-((phenylamino)methyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | CHEMBL523037
TypeSmall organic molecule
Emp. Form.C22H25N5
Mol. Mass.359.4674
SMILESN#Cc1ncc2cc(CNc3ccccc3)n(CCC3CCCCC3)c2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a