Reaction Details Report a problem with these data
Target
Bcl-2-like protein 2
Ligand
BDBM50251652
Substrate
n/a
Meas. Tech.
ChEMBL_488051 (CHEMBL983861)
Ki
9430±n/a nM
Citation
 Dömling, A; Antuch, W; Beck, B; Schauer-Vukasinovic, V Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-XL protein interaction antagonist. Bioorg Med Chem Lett 18:4115-7 (2008) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM50251652
Synonyms:
Biphenyl-4-carboxylic acid {[4-(adamantan-1-ylamino)-3-nitro-phenylcarbamoyl]-methyl}-methyl-amide | CHEMBL521253
Type:
Small organic molecule
Emp. Form.:
C32H34N4O4
Mol. Mass.:
538.6368
SMILES:
CN(CC(=O)Nc1ccc(NC23CC4CC(CC(C4)C2)C3)c(c1)[N+]([O-])=O)C(=O)c1ccc(cc1)-c1ccccc1 |TLB:10:11:14:18.17.16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11|
Structure:
Search PDB for entries with ligand similarity: