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Target
Lysosomal alpha-mannosidase
Ligand
BDBM50263047
Substrate
n/a
Meas. Tech.
ChEMBL_489067 (CHEMBL987287)
IC50
200000±n/a nM
Citation
 Fiaux, H; Kuntz, DA; Hoffman, D; Janzer, RC; Gerber-Lemaire, S; Rose, DR; Juillerat-Jeanneret, L Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site. Bioorg Med Chem 16:7337-46 (2008) [PubMed]  Article 
Target
Name:
Lysosomal alpha-mannosidase
Synonyms:
LAMAN | MA2B1_HUMAN | MAN2B1 | MANB
Type:
PROTEIN
Mol. Mass.:
113753.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1432452
Residue:
1011
Sequence:
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
  
Inhibitor
Name:
BDBM50263047
Synonyms:
(R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate | CHEMBL476718
Type:
Small organic molecule
Emp. Form.:
C20H23BrN2O4
Mol. Mass.:
435.312
SMILES:
O[C@H]1CN[C@H](CN[C@@H](COC(=O)c2ccc(Br)cc2)c2ccccc2)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: