Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 1
Ligand
BDBM50214095
Substrate
n/a
Meas. Tech.
ChEMBL_513579 (CHEMBL967075)
IC50
0.7±n/a nM
Citation
Bharate, SB; Mahajan, TR; Gole, YR; Nambiar, M; Matan, TT; Kulkarni-Almeida, A; Balachandran, S; Junjappa, H; Balakrishnan, A; Vishwakarma, RA Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-alpha and IL-6 inhibitors. Bioorg Med Chem 16:7167-76 (2008) [PubMed] Article
More Info.:
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Inhibitor
Name:
BDBM50214095
Synonyms:
CHEMBL248713 | CHEMBL511394 | N-((5-(3-(5-fluoro-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)methyl)ethanamine
Type:
Small organic molecule
Emp. Form.:
C21H18FN7
Mol. Mass.:
387.4129
SMILES:
CCNCc1cncc(c1)-c1cnc2n[nH]c(-c3nc4ccc(F)cc4[nH]3)c2c1