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Target
Acyl-CoA desaturase 1
Ligand
BDBM50262531
Substrate
n/a
Meas. Tech.
ChEMBL_514601 (CHEMBL979979)
IC50
700±n/a nM
Citation
 Xin, Z; Zhao, H; Serby, MD; Liu, B; Liu, M; Szczepankiewicz, BG; Nelson, LT; Smith, HT; Suhar, TS; Janis, RS; Cao, N; Camp, HS; Collins, CA; Sham, HL; Surowy, TK; Liu, G Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg Med Chem Lett 18:4298-302 (2008) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50262531
Synonyms:
CHEMBL476103 | N-(3-(methylcarbamoyl)phenyl)-4-(2-(trifluoromethyl)benzoyl)piperazine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H21F3N4O3
Mol. Mass.:
434.4116
SMILES:
CNC(=O)c1cccc(NC(=O)N2CCN(CC2)C(=O)c2ccccc2C(F)(F)F)c1
Structure:
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