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Target
Cyclin-dependent kinase 4
Ligand
BDBM50272873
Substrate
n/a
Meas. Tech.
ChEMBL_513702 (CHEMBL974552)
IC50
38000±n/a nM
Citation
 Jenkins, PR; Wilson, J; Emmerson, D; Garcia, MD; Smith, MR; Gray, SJ; Britton, RG; Mahale, S; Chaudhuri, B Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. Bioorg Med Chem 16:7728-39 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50272873
Synonyms:
CHEMBL497454 | N-(2-(1H-Indol-3-yl)ethyl)-4'-fluorobiphenyl-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H19FN2O
Mol. Mass.:
358.4082
SMILES:
Fc1ccc(cc1)-c1ccccc1C(=O)NCCc1c[nH]c2ccccc12
Structure:
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