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Target
Cyclin-dependent kinase 2
Ligand
BDBM50272874
Substrate
n/a
Meas. Tech.
ChEMBL_513701 (CHEMBL974551)
IC50
262000±n/a nM
Citation
 Jenkins, PR; Wilson, J; Emmerson, D; Garcia, MD; Smith, MR; Gray, SJ; Britton, RG; Mahale, S; Chaudhuri, B Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. Bioorg Med Chem 16:7728-39 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50272874
Synonyms:
CHEMBL525530 | N-(2-(1H-Indol-3-yl)ethyl)-4'-tert-butylbiphenyl-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C27H28N2O
Mol. Mass.:
396.524
SMILES:
CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)NCCc1c[nH]c2ccccc12
Structure:
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