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Target
Aryl hydrocarbon receptor
Ligand
BDBM50240990
Substrate
n/a
Meas. Tech.
ChEMBL_510004 (CHEMBL1005597)
Ki
6.8±n/a nM
Citation
 Aiello, S; Wells, G; Stone, EL; Kadri, H; Bazzi, R; Bell, DR; Stevens, MF; Matthews, CS; Bradshaw, TD; Westwell, AD Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). J Med Chem 51:5135-9 (2008) [PubMed]  Article 
Target
Name:
Aryl hydrocarbon receptor
Synonyms:
AHR_RAT | Ahr
Type:
PROTEIN
Mol. Mass.:
96224.95
Organism:
Rattus norvegicus
Description:
ChEMBL_510004
Residue:
853
Sequence:
MSSGANITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRSRGQDQCRAQVRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTDSAQGVDETHGLPQPAVYYTPDQLPPENTAFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCNKGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSMTLPFMFATGEAVLYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPNSLMSALIQQDESIYLCPPSSPAPLDSHFLMDSMSECGSWQGSFAVASNEALLKHEEIRHTQDVNLTLSGGPSELFPDNKNNDLYSIMRNLGIDFEDIRSMQNEEFFRTDSSGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVSQHLSCMLQERLQLEQQQQLQQQHPTQTLEPQRQLCQVEVPQHELGQKTKHMQVNGMFASWNPAPPVSFSCPQQERKHYSLFSGLQGTAQEFPYKSEVDSMPYTQNFAPCNQSLLPEHSKGTQLDFPGRDFERSLHPNASNLEDFVSCLQVPENQRHGINSQSAMVSPQAYYAGAMSMYQCQAGPQHTPVDQMQYSPEIPGSQAFLSKFQSPSILNEAYSADLSSIGHLQTAAHLPRLAEAQPLPDITPSGFL
  
Inhibitor
Name:
BDBM50240990
Synonyms:
2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole | 5-fluoro-2-(3,4-dimethoxyphenyl)benzothiazole | CHEMBL373251 | NSC-721648
Type:
Small organic molecule
Emp. Form.:
C15H12FNO2S
Mol. Mass.:
289.325
SMILES:
COc1ccc(cc1OC)-c1nc2cc(F)ccc2s1
Structure:
Search PDB for entries with ligand similarity: