Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM50268097
Substrate
n/a
Meas. Tech.
ChEMBL_521105 (CHEMBL960366)
IC50
2.8±n/a nM
Citation
 Andrianov, V; Gailite, V; Lola, D; Loza, E; Semenikhina, V; Kalvinsh, I; Finn, P; Petersen, KD; Ritchie, JW; Khan, N; Tumber, A; Collins, LS; Vadlamudi, SM; Björkling, F; Sehested, M Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR. Eur J Med Chem 44:1067-85 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50268097
Synonyms:
6-{[2-(9H-Fluoren-9-yliden)acetyl]amino}-N-hydroxyhexanamide | CHEMBL485514
Type:
Small organic molecule
Emp. Form.:
C21H22N2O3
Mol. Mass.:
350.411
SMILES:
[#8]-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)\[#6]=[#6]-1\c2ccccc2-c2ccccc-12
Structure:
Search PDB for entries with ligand similarity: