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Target
Cyclin-dependent kinase 1
Ligand
BDBM50245442
Substrate
n/a
Meas. Tech.
ChEMBL_512836 (CHEMBL972549)
IC50
>100000±n/a nM
Citation
 Hughes, TV; Xu, G; Wetter, SK; Connolly, PJ; Emanuel, SL; Karnachi, P; Pollack, SR; Pandey, N; Adams, M; Moreno-Mazza, S; Middleton, SA; Greenberger, LM A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity. Bioorg Med Chem Lett 18:4896-9 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM50245442
Synonyms:
3-fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate | CHEMBL472382
Type:
Small organic molecule
Emp. Form.:
C25H20ClFN4O3
Mol. Mass.:
478.903
SMILES:
Nc1ncnc(Nc2ccc(OCc3ccccc3)c(Cl)c2)c1C(=O)OCc1cccc(F)c1
Structure:
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