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Target
Ras guanyl-releasing protein 3
Ligand
BDBM50244643
Substrate
n/a
Meas. Tech.
ChEMBL_512396 (CHEMBL979907)
Ki
4.68±n/a nM
Citation
Duan, D; Sigano, DM; Kelley, JA; Lai, CC; Lewin, NE; Kedei, N; Peach, ML; Lee, J; Abeyweera, TP; Rotenberg, SA; Kim, H; Kim, YH; El Kazzouli, S; Chung, JU; Young, HA; Young, MR; Baker, A; Colburn, NH; Haimovitz-Friedman, A; Truman, JP; Parrish, DA; Deschamps, JR; Perry, NA; Surawski, RJ; Blumberg, PM; Marquez, VE Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem 51:5198-220 (2008) [PubMed] Article
More Info.:
Target
Name:
Ras guanyl-releasing protein 3
Synonyms:
GRP3 | GRP3_HUMAN | KIAA0846 | RAS guanyl releasing protein 3 | RASGRP3
Type:
PROTEIN
Mol. Mass.:
78335.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1364407
Residue:
690
Sequence:
MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG
Inhibitor
Name:
BDBM50244643
Synonyms:
CHEMBL452307 | rac-(E)-(4-{[4-(Dimethylamino)phenyl]methylene}-2-(hydroxymethyl)-5-oxo-2-2,3-dihydrofuryl)methyl 4-(Dimethylamino)benzoate | rac-(E/Z)-(4-(4-(dimethylamino)benzylidene)-2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl)methyl 4-(dimethylamino)benzoate
Type:
Small organic molecule
Emp. Form.:
C24H28N2O5
Mol. Mass.:
424.4895
SMILES:
CN(C)c1ccc(\C=C2/CC(CO)(COC(=O)c3ccc(cc3)N(C)C)OC2=O)cc1