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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50263370
Substrate
n/a
Meas. Tech.
ChEMBL_536131 (CHEMBL983585)
EC50
>50000±n/a nM
Citation
 Bridges, TM; Brady, AE; Kennedy, JP; Daniels, RN; Miller, NR; Kim, K; Breininger, ML; Gentry, PR; Brogan, JT; Jones, CK; Conn, PJ; Lindsley, CW Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg Med Chem Lett 18:5439-42 (2008) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50263370
Synonyms:
1-(1'-(2-(trifluoromethyl)benzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | 1-[1'-(2-Trifluoromethyl-benzyl)-[1,4']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one | CHEMBL478662
Type:
Small organic molecule
Emp. Form.:
C25H29F3N4O
Mol. Mass.:
458.5192
SMILES:
FC(F)(F)c1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O
Structure:
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