Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM50275726
Substrate
n/a
Meas. Tech.
ChEMBL_496808 (CHEMBL1008821)
IC50
835±n/a nM
Citation
 Blagg, J; Mowbray, C; Pryde, DC; Salmon, G; Schmid, E; Fairman, D; Beaumont, K Small, non-peptide C5a receptor antagonists: part 1. Bioorg Med Chem Lett 18:5601-4 (2008) [PubMed]  Article 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM50275726
Synonyms:
CHEMBL520381 | N-(4-chlorophenethyl)-2-isopropoxy-N-(1,4-dioxaspiro[4.5]decan-8-yl)nicotinamide
Type:
Small organic molecule
Emp. Form.:
C25H31ClN2O4
Mol. Mass.:
458.978
SMILES:
CC(C)Oc1ncccc1C(=O)N(CCc1ccc(Cl)cc1)C1CCC2(CC1)OCCO2
Structure:
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