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Target
Acetylcholinesterase
Ligand
BDBM10625
Substrate
n/a
Meas. Tech.
ChEMBL_534770 (CHEMBL986294)
IC50
2500±n/a nM
Citation
 Carolan, CG; Dillon, GP; Gaynor, JM; Reidy, S; Ryder, SA; Khan, D; Marquez, JF; Gilmer, JF Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem 51:6400-9 (2008) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache
Type:
Enzyme
Mol. Mass.:
71812.79
Organism:
Electrophorus electricus (Electric eel)
Description:
n/a
Residue:
633
Sequence:
MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFAEPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLYLNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGFLALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDSRPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLIDQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYGAPGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIVGDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHRASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINVDGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAERQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
  
Inhibitor
Name:
BDBM10625
Synonyms:
({[bis(propan-2-ylamino)phosphoryl]oxy}(propan-2-ylamino)phosphoryl)(propan-2-yl)amine | CHEMBL494887 | iso-OMPA | tetra(monoisopropyl)pyrophosphortetramide
Type:
Small organic molecule
Emp. Form.:
C12H32N4O3P2
Mol. Mass.:
342.355
SMILES:
CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C
Structure:
Search PDB for entries with ligand similarity: