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Target
Histone deacetylase 2
Ligand
BDBM50232034
Substrate
n/a
Meas. Tech.
ChEMBL_493107 (CHEMBL940370)
IC50
390±n/a nM
Citation
 Methot, JL; Hamblett, CL; Mampreian, DM; Jung, J; Harsch, A; Szewczak, AA; Dahlberg, WK; Middleton, RE; Hughes, B; Fleming, JC; Wang, H; Kral, AM; Ozerova, N; Cruz, JC; Haines, B; Chenard, M; Kenific, CM; Secrist, JP; Miller, TA SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett 18:6104-9 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50232034
Synonyms:
CHEMBL256440 | N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide
Type:
Small organic molecule
Emp. Form.:
C16H13N3OS
Mol. Mass.:
295.359
SMILES:
Nc1ccc(cc1NC(=O)c1cccnc1)-c1cccs1
Structure:
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