Target
Histone deacetylase 1
Ligand
BDBM50276027
Substrate
n/a
Meas. Tech.
ChEMBL_493106 (CHEMBL940369)
IC50
29±n/a nM
Citation
 Methot, JLHamblett, CLMampreian, DMJung, JHarsch, ASzewczak, AADahlberg, WKMiddleton, REHughes, BFleming, JCWang, HKral, AMOzerova, NCruz, JCHaines, BChenard, MKenific, CMSecrist, JPMiller, TA SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett 18:6104-9 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50276027
Synonyms:
CHEMBL470148 | N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-hydroxy-8-azaspiro[4.5]decan-8-yl)nicotinamide
Type:
Small organic molecule
Emp. Form.:
C25H28N4O2S
Mol. Mass.:
448.58
SMILES:
Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CCCC2O)CC1)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: