Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM50275827
Substrate
n/a
Meas. Tech.
ChEMBL_493108 (CHEMBL940371)
IC50
>30000000±n/a nM
Citation
 Methot, JL; Hamblett, CL; Mampreian, DM; Jung, J; Harsch, A; Szewczak, AA; Dahlberg, WK; Middleton, RE; Hughes, B; Fleming, JC; Wang, H; Kral, AM; Ozerova, N; Cruz, JC; Haines, B; Chenard, M; Kenific, CM; Secrist, JP; Miller, TA SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett 18:6104-9 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50275827
Synonyms:
CHEMBL472252 | N-(2-amino-5-(1-methyl-1H-imidazol-4-yl)phenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide
Type:
Small organic molecule
Emp. Form.:
C24H29N7O
Mol. Mass.:
431.5334
SMILES:
Cn1cnc(c1)-c1ccc(N)c(NC(=O)c2ccc(nc2)N2CCC3(CCNC3)CC2)c1
Structure:
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