Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetThyroid hormone receptor
LigandBDBM50274809
Substrate/Competitorn/a
Meas. Tech.ChEMBL_493724
Ki 1.84±n/a nM
Citation Boyer, SHJiang, HJacintho, JDReddy, MVLi, HLi, WGodwin, JLSchulz, WGCable, EEHou, JWu, RFujitaki, JMHecker, SJErion, MD Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. J Med Chem51:7075-93 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thyroid hormone receptor
Name:Thyroid hormone receptor
Synonyms:C-erbA-alpha | EAR-7 | EAR7 | Nuclear receptor subfamily 1 group A member 1 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | c-erbA-1
Type:Receptor
Mol. Mass.:54818.00
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1.
Residue:490
Sequence:
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50274809
NameBDBM50274809
Synonyms:3,5-Diiodo-4-(4'-hydroxy-3'-isopropylphenoxy)benzylphosphonicAcid | CHEMBL512383
TypeSmall organic molecule
Emp. Form.C16H17I2O5P
Mol. Mass.574.0859
SMILESCC(C)c1cc(Oc2c(I)cc(CP(O)(O)=O)cc2I)ccc1O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a