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TargetThyroid Hormone Receptor (TR-beta)
LigandBDBM50275259
Substrate/Competitorn/a
Meas. Tech.ChEMBL_493725
Ki 87±n/a nM
Citation Boyer, SHJiang, HJacintho, JDReddy, MVLi, HLi, WGodwin, JLSchulz, WGCable, EEHou, JWu, RFujitaki, JMHecker, SJErion, MD Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. J Med Chem51:7075-93 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thyroid Hormone Receptor (TR-beta)
Name:Thyroid hormone receptor
Synonyms:Nuclear receptor subfamily 1 group A member 2 | Thyroid hormone receptor | Thyroid hormone receptor beta
Type:Receptor
Mol. Mass.:52793.62
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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  Blast E-value cutoff:
BDBM50275259
NameBDBM50275259
Synonyms:CHEMBL447378 | [3,5-Dimethoxy-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy]ethylphosphonicAcid
TypeSmall organic molecule
Emp. Form.C20H27O5P
Mol. Mass.378.3991
SMILESCC(C)c1cc(Cc2c(C)cc(OCCP(O)(O)=O)cc2C)ccc1O
Structure
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