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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50256614
Substrate
n/a
Meas. Tech.
ChEMBL_519297 (CHEMBL947749)
EC50
17±n/a nM
Citation
 Roberts, LR; Bryans, J; Conlon, K; McMurray, G; Stobie, A; Whitlock, GA Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists. Bioorg Med Chem Lett 18:6437-40 (2008) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50256614
Synonyms:
3-fluoro-1-((2,3-dihydro-1-(1H-imidazol-2-yl)-1H-inden-4-yl)methyl)-1H-pyrazole | CHEMBL514333
Type:
Small organic molecule
Emp. Form.:
C16H15FN4
Mol. Mass.:
282.3155
SMILES:
Fc1ccn(Cc2cccc3C(CCc23)c2ncc[nH]2)n1
Structure:
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