Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50245834
Substrate
n/a
Meas. Tech.
ChEMBL_559710 (CHEMBL1012868)
IC50
52000±n/a nM
Citation
 Yi, W; Cao, R; Wen, H; Yan, Q; Zhou, B; Wan, Y; Ma, L; Song, H Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorg Med Chem Lett 18:6490-3 (2008) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50245834
Synonyms:
4-((2R,4aR,6S,7R,8S,8aS)-7,8-dihydroxy-2-phenyl-hexahydropyrano[3,2-d][1,3]dioxin-6-yloxy)benzaldehyde | CHEMBL455398
Type:
Small organic molecule
Emp. Form.:
C20H20O7
Mol. Mass.:
372.3686
SMILES:
O[C@@H]1[C@H](O)[C@@H]2O[C@@H](OC[C@H]2O[C@H]1Oc1ccc(C=O)cc1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: