Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50254697
Substrate
n/a
Meas. Tech.
ChEMBL_559919 (CHEMBL1013713)
IC50
660±n/a nM
Citation
 Vaccaro, WHuynh, TLloyd, JAtwal, KFinlay, HJLevesque, PConder, MLJenkins-West, TShi, HSun, L Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)). Bioorg Med Chem Lett 18:6381-5 (2008) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50254697
Synonyms:
(7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)(pyrrolidin-1-yl)methanone | CHEMBL465276
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2N4O
Mol. Mass.:
377.268
SMILES:
CC1=Nc2ccnn2C(C1C(=O)N1CCCC1)c1ccc(Cl)c(Cl)c1 |t:1|
Structure:
Search PDB for entries with ligand similarity: