Reaction Details Report a problem with these data
Target
Protein-tyrosine kinase 6
Ligand
BDBM50273637
Substrate
n/a
Meas. Tech.
ChEMBL_537097 (CHEMBL988929)
Kd
2±n/a nM
Citation
 Bamborough, P; Drewry, D; Harper, G; Smith, GK; Schneider, K Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem 51:7898-914 (2008) [PubMed]  Article 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM50273637
Synonyms:
3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenol | CHEMBL450519
Type:
Small organic molecule
Emp. Form.:
C17H19N5O
Mol. Mass.:
309.3657
SMILES:
Nc1ncnc2n(cc(-c3cccc(O)c3)c12)C1CCNCC1
Structure:
Search PDB for entries with ligand similarity: