Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50254430
Substrate
n/a
Meas. Tech.
ChEMBL_559523 (CHEMBL1018996)
Ki
48.5±n/a nM
Citation
 Baek, YS; Ryu, YB; Curtis-Long, MJ; Ha, TJ; Rengasamy, R; Yang, MS; Park, KH Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. Bioorg Med Chem 17:35-41 (2008) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50254430
Synonyms:
CHEMBL468906 | broussonin C
Type:
Small organic molecule
Emp. Form.:
C20H24O3
Mol. Mass.:
312.4028
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1cc(-[#6]-[#6]-[#6]-c2ccc(-[#8])cc2-[#8])ccc1-[#8]
Structure:
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