Reaction Details Report a problem with these data
Target
Hydroxysteroid 11-beta dehydrogenase 1
Ligand
BDBM50273458
Substrate
n/a
Meas. Tech.
ChEMBL_561246 (CHEMBL1013601)
IC50
45±n/a nM
Citation
 Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Véniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. J Med Chem 51:7953-67 (2008) [PubMed]  Article 
Target
Name:
Hydroxysteroid 11-beta dehydrogenase 1
Synonyms:
11-beta-hydroxysteroid dehydrogenase type 1
Type:
PROTEIN
Mol. Mass.:
32020.70
Organism:
Canis familiaris
Description:
ChEMBL_850498
Residue:
293
Sequence:
MAFKKKYLPPLLGFFLAYYYYSANEEFRPEMLQGKKVIVTGASKGIGEQMAYHLAKMGAHVVVTARSKETLKKVVSHCLELGAASAHYIPGTMEDMTFAEQFVAKAGKLMGGLDMLILNHITNTSMNLFSGDIHLVRRSMEVNFLSYVVLSAAALPMLKQSNGSIVVVSSKAGKMSSPLVAPYSASKFALDGFFSSVRMEHSVTKVNVSITLCILGLINTDTAMKAVSGILSTVGASSKEECALEIIKGGALRQEEVYYDNSVWTAFLLGNPGRKILEFLSLRSYKLDKFINN
  
Inhibitor
Name:
BDBM50273458
Synonyms:
(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one | (S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one | CHEMBL455907
Type:
Small organic molecule
Emp. Form.:
C15H19FN2O2S
Mol. Mass.:
310.387
SMILES:
C[C@H](NC1=NC(=O)[C@@](C)(S1)C(C)(C)O)c1ccc(F)cc1 |r,t:3|
Structure:
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