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Target
D(3) dopamine receptor
Ligand
BDBM50020222
Substrate
n/a
Meas. Tech.
ChEMBL_561955 (CHEMBL1010018)
Ki
6.19±n/a nM
Citation
 Brown, DA; Kharkar, PS; Parrington, I; Reith, ME; Dutta, AK Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model. J Med Chem 51:7806-19 (2008) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50020222
Synonyms:
(+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol | (+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin | (R,S) 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol | 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol | 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol | 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol (DP-7-ADTN) | 7-OH-DPAT | 7-OH-DPAT,(+) | 7-OH-DPAT,(-) | 7-hydroxy-2-(dipropylamino)tetralin | CHEMBL1255966 | CHEMBL285755
Type:
Small organic molecule
Emp. Form.:
C16H25NO
Mol. Mass.:
247.3758
SMILES:
CCCN(CCC)C1CCc2ccc(O)cc2C1
Structure:
Search PDB for entries with ligand similarity: