Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50247069
Substrate
n/a
Meas. Tech.
ChEMBL_557558 (CHEMBL955001)
IC50
52500±n/a nM
Citation
 Wei, D; Jiang, X; Zhou, L; Chen, J; Chen, Z; He, C; Yang, K; Liu, Y; Pei, J; Lai, L Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem 51:7882-8 (2008) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50247069
Synonyms:
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine | CHEMBL460302
Type:
Small organic molecule
Emp. Form.:
C17H18N2O
Mol. Mass.:
266.3376
SMILES:
NCCc1c[nH]c2c(OCc3ccccc3)cccc12
Structure:
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