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Target
Carbonyl reductase [NADPH] 1
Ligand
BDBM9461
Substrate
n/a
Meas. Tech.
ChEMBL_495288 (CHEMBL1004505)
IC50
12710±n/a nM
Citation
 Zimmermann, TJ; Niesen, FH; Pilka, ES; Knapp, S; Oppermann, U; Maier, ME Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. Bioorg Med Chem 17:530-6 (2009) [PubMed]  Article 
Target
Name:
Carbonyl reductase [NADPH] 1
Synonyms:
CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1
Type:
PROTEIN
Mol. Mass.:
30380.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_607770
Residue:
277
Sequence:
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
  
Inhibitor
Name:
BDBM9461
Synonyms:
5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one | Biochanin A (2) | Biochanin A (BCA) | Biochanin A, 9 | CHEMBL131921 | cid_5280373
Type:
Small organic molecule
Emp. Form.:
C16H12O5
Mol. Mass.:
284.2635
SMILES:
COc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
Structure:
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