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Target
Beta-1 adrenergic receptor
Ligand
BDBM50255803
Substrate
n/a
Meas. Tech.
ChEMBL_516105 (CHEMBL983249)
Ki
11±n/a nM
Citation
 Marona, H; Szkaradek, N; Rapacz, A; Filipek, B; Dybala, M; Siwek, A; Cegla, M; Szneler, E Preliminary evaluation of pharmacological properties of some xanthone derivatives. Bioorg Med Chem 17:1345-52 (2009) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1R, B1AR | ADRB1_RAT | Adrb1 | Adrb1r | Adrenergic receptor beta | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 | adrenergic Beta1,2
Type:
Protein
Mol. Mass.:
50486.84
Organism:
Rattus norvegicus (Rat)
Description:
P18090
Residue:
466
Sequence:
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
  
Inhibitor
Name:
BDBM50255803
Synonyms:
5-(3N-(2-Amino-2-methyl-1-hydroxypropyl)-2-hydroxypropoxy)-3-chloro-9H-xanthen-9-one hydrochloride | CHEMBL520600
Type:
Small organic molecule
Emp. Form.:
C20H22ClNO5
Mol. Mass.:
391.845
SMILES:
CC(C)(CO)NCC(O)COc1cccc2c1oc1cc(Cl)ccc1c2=O
Structure:
Search PDB for entries with ligand similarity: