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Target
Thrombopoietin receptor
Ligand
BDBM50247936
Substrate
n/a
Meas. Tech.
ChEMBL_543527 (CHEMBL1019476)
EC50
129±n/a nM
Citation
 Munchhof, MJ; Antipas, AS; Blumberg, LC; Brissette, WH; Brown, MF; Casavant, JM; Doty, JL; Driscoll, J; Harris, TM; Wolf-Gouveia, LA; Jones, CS; Li, Q; Linde, RG; Lira, PD; Marfat, A; McElroy, E; Mitton-Fry, M; McCurdy, SP; Reiter, LA; Ripp, SL; Shavnya, A; Thomasco, LM; Trevena, KA The identification of orally bioavailable thrombopoietin agonists. Bioorg Med Chem Lett 19:1428-30 (2009) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50247936
Synonyms:
4-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)pyridin-2-yl)piperazine-2-carboxylic acid | CHEMBL490096
Type:
Small organic molecule
Emp. Form.:
C21H16ClF4N5O3S
Mol. Mass.:
529.895
SMILES:
OC(=O)C1CN(CCN1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Structure:
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