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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50248168
Substrate
n/a
Meas. Tech.
ChEMBL_565909 (CHEMBL960804)
EC50
26.1±n/a nM
Citation
 Zhou, N; Zeller, W; Zhang, J; Onua, E; Kiselyov, AS; Ramirez, J; Palsdottir, G; Halldorsdottir, G; Andrésson, T; Gurney, ME; Singh, J 3-Acrylamide-4-aryloxyindoles: synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists. Bioorg Med Chem Lett 19:1528-31 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50248168
Synonyms:
3-(4-(2,4-dichlorophenoxy)-1-methyl-1H-indol-3-yl)-N-(3,4-difluorophenylsulfonyl)acrylamide | CHEMBL459885
Type:
Small organic molecule
Emp. Form.:
C24H16Cl2F2N2O4S
Mol. Mass.:
537.363
SMILES:
Cn1cc(\C=C\C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc12
Structure:
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