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Target
Neurotensin receptor type 1
Ligand
BDBM50248080
Substrate
n/a
Meas. Tech.
ChEMBL_566215 (CHEMBL963296)
EC50
986±n/a nM
Citation
 Thomas, JB; Navarro, H; Warner, KR; Gilmour, B The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay. Bioorg Med Chem Lett 19:1438-41 (2009) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM50248080
Synonyms:
(2R)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)-4-methylpentanoic acid | CHEMBL463227
Type:
Small organic molecule
Emp. Form.:
C27H27ClN4O5
Mol. Mass.:
522.98
SMILES:
COc1cccc(OC)c1-c1cc(nn1-c1ccnc2cc(Cl)ccc12)C(=O)N[C@H](CC(C)C)C(O)=O |r,wU:29.32,(-7.57,-14.92,;-6.23,-15.68,;-6.23,-17.22,;-7.56,-18,;-7.56,-19.54,;-6.22,-20.31,;-4.89,-19.54,;-3.55,-20.31,;-3.55,-21.85,;-4.9,-17.99,;-3.57,-17.21,;-2.16,-17.84,;-1.12,-16.69,;-1.9,-15.35,;-3.41,-15.68,;-4.56,-14.66,;-6.01,-15.15,;-7.17,-14.12,;-6.86,-12.6,;-5.39,-12.12,;-5.08,-10.63,;-3.62,-10.15,;-3.31,-8.64,;-2.47,-11.17,;-2.79,-12.67,;-4.25,-13.16,;.41,-16.84,;1.04,-18.25,;1.31,-15.59,;2.84,-15.75,;3.48,-17.14,;5.01,-17.29,;5.64,-18.69,;5.9,-16.05,;3.75,-14.5,;5.29,-14.65,;3.12,-13.09,)|
Structure:
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