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Target
Cathepsin S
Ligand
BDBM50249446
Substrate
n/a
Meas. Tech.
ChEMBL_499503 (CHEMBL1021995)
IC50
890±n/a nM
Citation
 Morley, AD; Kenny, PW; Burton, B; Heald, RA; Macfaul, PA; Mullett, J; Page, K; Porres, SS; Ribeiro, LR; Smith, P; Ward, S; Wilkinson, TJ 5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors. Bioorg Med Chem Lett 19:1658-61 (2009) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50249446
Synonyms:
5-amino-4-(isobutylamino)-6-(piperazin-1-yl)pyrimidine-2-carbonitrile | CHEMBL474484
Type:
Small organic molecule
Emp. Form.:
C13H21N7
Mol. Mass.:
275.3527
SMILES:
CC(C)CNc1nc(nc(N2CCNCC2)c1N)C#N
Structure:
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