Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50257956
Substrate
n/a
Meas. Tech.
ChEMBL_567024 (CHEMBL1029921)
IC50
1.4±n/a nM
Citation
 Sakamoto, T; Moriya, M; Haga, Y; Takahashi, T; Shibata, T; Okamoto, O; Nonoshita, K; Kitazawa, H; Hidaka, M; Gomori, A; Iwaasa, H; Ishihara, A; Kanatani, A; Fukami, T; Gao, YD; Macneil, DJ; Yang, L Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists. Bioorg Med Chem Lett 19:1564-8 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50257956
Synonyms:
CHEMBL524192 | N-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)-4-(2-(methylsulfonamido)phenyl)piperazine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H23ClN6O3S
Mol. Mass.:
474.964
SMILES:
CS(=O)(=O)Nc1ccccc1N1CCN(CC1)C(=O)Nc1cc(n[nH]1)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: