Reaction Details Report a problem with these data
Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50257561
Substrate
n/a
Meas. Tech.
ChEMBL_566054 (CHEMBL954319)
IC50
18±n/a nM
Citation
Hauze, DB; Chengalvala, MV; Cottom, JE; Feingold, IB; Garrick, L; Green, DM; Huselton, C; Kao, W; Kees, K; Lundquist, JT; Mann, CW; Mehlmann, JF; Rogers, JF; Shanno, L; Wrobel, J; Pelletier, JC Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template. Bioorg Med Chem Lett 19:1986-90 (2009) [PubMed] Article
More Info.:
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
Inhibitor
Name:
BDBM50257561
Synonyms:
2-(4-tert-butylphenyl)-4-(4-((2-methyl-1-propyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole | CHEMBL493344
Type:
Small organic molecule
Emp. Form.:
C29H38N6
Mol. Mass.:
470.6522
SMILES:
CCCn1cc(CN2CCN(CC2)c2cccc3[nH]c(nc23)-c2ccc(cc2)C(C)(C)C)nc1C