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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50256884
Substrate
n/a
Meas. Tech.
ChEMBL_562461 (CHEMBL1010964)
IC50
540±n/a nM
Citation
Pelletier, JC; Chengalvala, MV; Cottom, JE; Feingold, IB; Green, DM; Hauze, DB; Huselton, CA; Jetter, JW; Kopf, GS; Lundquist, JT; Magolda, RL; Mann, CW; Mehlmann, JF; Rogers, JF; Shanno, LK; Adams, WR; Tio, CO; Wrobel, JE Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). J Med Chem 52:2148-52 (2009) [PubMed] Article
More Info.:
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL