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Target
Histamine H3 receptor
Ligand
BDBM50278495
Substrate
n/a
Meas. Tech.
ChEMBL_501237 (CHEMBL975272)
Ki
0.068±n/a nM
Citation
 Isensee, K; Amon, M; Garlapati, A; Galaparti, A; Ligneau, X; Camelin, JC; Capet, M; Schwartz, JC; Stark, H Fluorinated non-imidazole histamine H3 receptor antagonists. Bioorg Med Chem Lett 19:2172-5 (2009) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50278495
Synonyms:
4-chloro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine | CHEMBL470609
Type:
Small organic molecule
Emp. Form.:
C20H31ClN2O
Mol. Mass.:
350.926
SMILES:
ClC1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1
Structure:
Search PDB for entries with ligand similarity: