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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50278162
Substrate
n/a
Meas. Tech.
ChEMBL_497574 (CHEMBL999421)
IC50
28.7±n/a nM
Citation
 Xie, Y; Liu, Y; Gong, G; Smith, DH; Yan, F; Rinderspacher, A; Feng, Y; Zhu, Z; Li, X; Deng, SX; Branden, L; Vidovic, D; Chung, C; Schürer, S; Morisseau, C; Hammock, BD; Landry, DW Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett 19:2354-9 (2009) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50278162
Synonyms:
CHEMBL469360 | N-(2-chloro-5-(trifluoromethyl)benzyl)-1-(mesitylsulfonyl)piperidine-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H26ClF3N2O3S
Mol. Mass.:
502.977
SMILES:
Cc1cc(C)c(c(C)c1)S(=O)(=O)N1CCC(CC1)C(=O)NCc1cc(ccc1Cl)C(F)(F)F
Structure:
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