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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50278185
Substrate
n/a
Meas. Tech.
ChEMBL_497574 (CHEMBL999421)
IC50
29.1±n/a nM
Citation
 Xie, Y; Liu, Y; Gong, G; Smith, DH; Yan, F; Rinderspacher, A; Feng, Y; Zhu, Z; Li, X; Deng, SX; Branden, L; Vidovic, D; Chung, C; Schürer, S; Morisseau, C; Hammock, BD; Landry, DW Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett 19:2354-9 (2009) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50278185
Synonyms:
CHEMBL469572 | N-(1-(4-chlorophenyl)ethyl)-1-(mesitylsulfonyl)piperidine-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H29ClN2O3S
Mol. Mass.:
449.006
SMILES:
CC(NC(=O)C1CCN(CC1)S(=O)(=O)c1c(C)cc(C)cc1C)c1ccc(Cl)cc1
Structure:
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