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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50267389
Substrate
n/a
Meas. Tech.
ChEMBL_562970 (CHEMBL1015369)
IC50
6599000±n/a nM
Citation
 Lainé, DI; McCleland, B; Thomas, S; Neipp, C; Underwood, B; Dufour, J; Widdowson, KL; Palovich, MR; Blaney, FE; Foley, JJ; Webb, EF; Luttmann, MA; Burman, M; Belmonte, K; Salmon, M Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. J Med Chem 52:2493-505 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50267389
Synonyms:
2-(hydroxydiphenylmethyl)-1-azoniabicyclo[2.2.2]octane bromide | CHEMBL476435
Type:
Small organic molecule
Emp. Form.:
C20H24NO
Mol. Mass.:
294.4101
SMILES:
OC(C1CC2CC[NH+]1CC2)(c1ccccc1)c1ccccc1 |(-4.05,-3.64,;-4.83,-2.31,;-6.17,-3.08,;-6.17,-4.63,;-7.51,-5.4,;-8.84,-4.63,;-8.84,-3.08,;-7.51,-2.3,;-8.14,-3.48,;-6.86,-4.11,;-3.51,-1.53,;-2.18,-2.29,;-.85,-1.51,;-.87,.02,;-2.22,.78,;-3.53,-.01,;-5.6,-.98,;-4.83,.35,;-5.6,1.69,;-7.14,1.69,;-7.91,.35,;-7.14,-.98,)|
Structure:
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