Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50267257
Substrate
n/a
Meas. Tech.
ChEMBL_563053 (CHEMBL1011883)
EC50
0.5±n/a nM
Citation
 Vachal, P; Fletcher, JM; Fong, TM; Huang, CC; Lao, J; Xiao, JC; Shen, CP; Strack, AM; Shearman, L; Stribling, S; Chen, RZ; Frassetto, A; Tong, X; Wang, J; Ball, RG; Tsou, NN; Hickey, GJ; Thompson, DF; Faidley, TD; Nicolich, S; Achanfuo-Yeboah, J; Hora, DF; Hale, JJ; Hagmann, WK 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. J Med Chem 52:2550-8 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50267257
Synonyms:
4-(2-(4-(3,5-dichlorophenylsulfonyl)piperazin-1-yl)-2-oxoethyl)benzonitrile | CHEMBL515641
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2N3O3S
Mol. Mass.:
438.328
SMILES:
Clc1cc(Cl)cc(c1)S(=O)(=O)N1CCN(CC1)C(=O)Cc1ccc(cc1)C#N
Structure:
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