Reaction Details Report a problem with these data
Target
Cytochrome P450 2D6
Ligand
BDBM50259018
Substrate
n/a
Meas. Tech.
ChEMBL_500937 (CHEMBL971452)
IC50
20000±n/a nM
Citation
 Clutterbuck, LA; Posada, CG; Visintin, C; Riddall, DR; Lancaster, B; Gane, PJ; Garthwaite, J; Selwood, DL Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem 52:2694-707 (2009) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50259018
Synonyms:
CHEMBL467283 | Tert-butyl(5-(1-(3-methylbenzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methylcarbamate
Type:
Small organic molecule
Emp. Form.:
C23H25N5O3
Mol. Mass.:
419.4763
SMILES:
Cc1cccc(Cn2nc(-c3nc(CNC(=O)OC(C)(C)C)no3)c3ccccc23)c1
Structure:
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